Codeine: the ‘safe' analgesic?
نویسندگان
چکیده
منابع مشابه
Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease.
After postoperative deaths in children who were prescribed codeine, several pediatric hospitals have removed it from their formularies. These deaths were attributed to atypical cytochrome P450 2D6 (CYP2D6) pharmacogenetics, which is also implicated in poor analgesic response. Because codeine is often prescribed to patients with sickle cell disease and is now the only Schedule III opioid analges...
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Acute and chronic pain often requires a multimodal approach. Combination therapy reduces the number of individual daily administrations and improves patient's compliance with the prescribed analgesic treatment. Despite the association codeine/paracetamol is one of the most widely used central analgesic, the exact mechanism of action, particularly of paracetamol, is still object of pharmacologic...
متن کاملDo codeine and caffeine enhance the analgesic effect of aspirin?--A systematic overview.
OBJECTIVE To assess whether codeine and caffeine enhance the analgesic effect of aspirin in post-operative pain. METHOD Systematic overview of the literature and meta-analysis of published randomized controlled trials (RCTs). RESULTS Codeine 60 mg leads to a small increase in the analgesic effect of 650 mg of aspirin when total pain relief score (TOTPAR%) is used as a efficacy end-point. Th...
متن کاملPharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability.
BACKGROUND Codeine analgesia is wholly or mostly due to its metabolism to morphine by the cytochrome P450 enzyme CYP2D6, which shows significant genetic variation in activity. The aims of this study were to investigate genotype, phenotype and morphine production from codeine in children undergoing adenotonsillectomy, and to compare analgesia from codeine or morphine combined with diclofenac. ...
متن کاملSearching for a safe analgesic in patients with cardiovascular disease.
Painful musculoskeletal conditions commonly coexist with cardiovascular disease. Older persons with elevated body mass index are at risk of degenerative arthritis, and low back pain as well as cardiovascular disease. Inflammatory arthritis, including rheumatoid arthritis, lupus, and psoriatic arthritis, are associated with an elevated risk of cardiovascular events. The overlapping epidemiology ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2013
ISSN: 0007-0912
DOI: 10.1093/bja/aet085